Functional Interactions between Herpesvirus Oncoprotein MEQ and Cell Cycle Regulator CDK2
نویسندگان
چکیده
منابع مشابه
Functional interactions between herpesvirus oncoprotein MEQ and cell cycle regulator CDK2.
Marek's disease virus, an avian alphaherpesvirus, has been used as an excellent model to study herpesvirus oncogenesis. One of its potential oncogenes, MEQ, has been demonstrated to transform a rodent fibroblast cell line, Rat-2, in vitro by inducing morphological transformation and anchorage- and serum-independent growth and by protecting cells from apoptosis induced by tumor necrosis factor a...
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Marek's disease virus (MDV) induces the rapid development of overwhelming T-cell lymphomas in chickens. One of its candidate oncogenes, meq (MDV Eco Q) which encodes a bZIP protein, has been biochemically characterized as a transcription factor. Interestingly, MEQ proteins are expressed not only in the nucleoplasm but also in the coiled bodies and the nucleolus. Its novel subcellular localizati...
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Marek's disease virus (MDV) is one of the most oncogenic herpesviruses and induces T lymphomas in chickens within weeks after infection. Only a limited number of viral transcripts are detected in MDV tumor samples and cell lines. One of the major transcripts encodes MEQ, a 339-amino-acid bZIP protein which is homologous to the Jun/Fos family of transcription factors. The C-terminal half of MEQ ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1999
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.73.5.4208-4219.1999